vorpX can only affect games while it is running and enabled. If it is not running or disabled, it cannot have an influnece on anything on your PC.
When it is running vorpX tries to hook into any DiretX9-11 and OpenGL game you start, including many native VR games. You can deal with that in two ways: either by disabling vorpX from the its tray icon right click menu before you start a native VR game or by adding the native game in question to the exclude list in the vorpX config app. vorpX will never try to hook into games/apps on the exclude list.