In several ways the best solution to your issue would be switching to the original DX9 Bioshock, for which vorpX provides better DirectVR support.
If you only have the remastered version:
Sounds like something is getting severely in the way if not even a hook helper helps. Try to disable everything you may have running in the background that potentially also hooks into games. E.g. any kind GPU utility, chat apps and generally everything that show overlays in game.
even if I close all background applications, which are not absolutely necessary to run the game, it does not work.
All other games work fine with Vorpx so I assume this issue has something to do with the game itself.
Not much else I can suggest that I didn’t suggest above already.
Not really a big deal if you can’t make it work in this case. Just use the original DX9 version instead. ‘Remastered’ may sound like ‘better’, but that’s not the case in terms of vorpX here. The original is the better choice.
The original version is still the better pick for vorpX. While ‘remastered’ may sound like ‘better’, that is not the case in terms of vorpX here. The profile for the original has the more advanced DirectVR capabilities.