For DX9-11 vorpX tries to hook everything automatically. For DX12 that isn’t the case yet, so if you have a DX12 game, you will have to a create copy of an existing DX12 profile in the config app and assign the main .exe the game you want to try to the profile copy.
Potential candidates that can be used as a bsse profile are e.g. Horizon Zero Dawn or Cyperpunk 2077.
If you want to learn more about creating user profiles, check the ‘user profiles’ section in the help. Covers the most important basics.