There is an Unreal Engine 5 profile. Just create a new one based on it, and add the .exe file (or the process if you can’t access it, and it will add the executable permanently anyway).
I used this method on Nightingale and it worked well :
https://www.vorpx.com/forums/topic/nightingale-2/
Adjust the resolution (game), FOV (game), zoom (VorpX) and headtracking speed (in this order) until it’s perfect.
If there’s no G3D that way I’d better play with Virtual Desktop + SuperDepth3D: 2880×2160 90hz, RivaTuner 45fps limit (Back Edge sync), LSFG 45→90fps, Codec HEVC 10-bit / h264+ , optionally with VorpX Desktop Viewer (depends on overall smoothness)