Thanks for everyones help. No, I had not run the game once by itself before trying it with VorpX. What is confusing is that I had no My Documents\My Games\… folder even though I’ve run at least two other Steam games on that PC. I did manually create that folder (and the Bioshock folder under it). Then I manually copied the template settings file from the games Steam folder to the newly created folder and finally the VorpX editor was able to find and edit the settings file. Next time I will try to run the game first before trying to configure it. Thanks again.