If the auto detection fails, you can try a vorpX desktop shortcut (right click the tray icon, choose “Create Desktop Shortcut”), which *may* be more reliable. There is still no guarantee though. Shortcuts often don’t work with Steam games for example.
It also helps to have a profile for the game, which you can create by copying another game’s profile (should be based on the same graphics engine for a chance of working 3d) in the config app and then assigning your game’s main .exe to this copied profile.