Game profiles are just settings for vorpx, which hooks to executable of the game, those settings/instructions point to specific memory addresses/exe parts to edit so if profile was made for steam version it might not work with gog version or disk version or a pirated game etc. Only way is to try. It should hook to a game once you launch since its waiting for you to start an executable of specific name.
Steamvr is probably the right choice if vr desktop already starts it.