I’m not exactly sure what’s going on, but as long as long as the Mixed Reality Portal is running, I can’t right-click vorpx’s systray icon. Left click still opens config, and as soon as I shut down the MR portal right click works again. I’m not exactly sure how long this has been happening, I only noticed it today while I was messing with getting a profile for the RE3 demo working.
Might be WMR automatically switching input to the headset. There is an option in the WMR settings where you can set that to manual: click the three dots in the bottom left corner of the WMR Portal window and then go to Settings > Headset Display > Input Switching.