First please understand this:
The gamepad override is necessary in many games that can’t handle mouse and gamepad input at the same time for mouse based head tracking: whenever vorpX emulates a mouse for head tracking the only viable alternative in affected games would be no gamepad at all.
If in an official profile the override is enabled, you can be 99% sure that is enabled for good reason.
That said:
You can configure (and disable) the override on the Input page the vorpX menu. If you either dont’ want head tracking or just want to check whether maybe inj a user profile the override is enabled although that wouldn’t have been necessary, there is no harm in trying.
If afterwards you encounter any headtracking dropouts or other strange input glitches, the override was necessary and you have to turn it on again.