The scan has to be run every time. In some games vorpX can cache the scan results, but not in Skyrim and Oblivion (at least not fully) since the memory location for the camera rotation changes with each program start.
If you see the restart hint every time you launch the games, please make sure that you have write access to their .ini files and that no other program changes the ini files. E.g. some mod launchers may write protect the ini files and/or change them. Try starting the games without the mod launcher running in that case.