Don’t like the extreme, crawly aliasing? You can force sparse-grid supersampling (SGSSAA) and it works with Vorpx. There is a performance hit but it’s less than I imagined it would be. It is extremely good at cleaning up aliasing. I would just disable the game’s ineffective anti-aliasing in the game’s menu. https://www.pcgamingwiki.com/wiki/Dishonored#Anti-aliasing_.28AA.29
Eventually you will get to a NPC dialog that will not work properly in DirectVR mode. The dialog options will not appear. Disabling DirectVR for that conversation is a fix.
Also, after a successful DirectVR scan you may still not be able to look around. Try climbing an in game object to fix that.