Please try without FOSE. While I’m not aware that it causes any issues, that can’t be ruled out either. Script extenders also hook into games like vorpX and may potentially cause a conflict if the do something that interferes with vorpX.
Also make sure not use any d3d9.dll replacement (e.g. from an ENB mod). That will definitely cause a conflict with vorpX.
If both doesn’t help, try without mods and if that helps, add your mods back one by one to find out which one caused the issue.
Are you using ReVive? I had an issue where Vorpx would try to hook with the ReVive process and after that nothing worked – I added revive.exe to the list of processes the vorpx was set to ignore and it appeared to fix it