First please make sure that there is a profile for the game. You can check that on the “Local Profiles” page of the vorpX config app. If there is no profile for the game, there is no guarantee that vorpX can hook into it.
If there is a profile for the game:
There might be an injection conflict with some other program on your PC. Many programs also hook into games and can cause such an issue. Not all of them are obvious.
Hottest candidates are: virus scanners, any sort of CPU/GPU utilities, game video recording/streaming software, chat programs and generally everything that can show notifictations in games.
Best way to trouble shoot this is to disable/uninstall programs running in the background.