vorpX will support games such as Morrowind, Oblivion, Skyrim, STALKER and System Shock 2. Those games usually can have lots of mods to enhance the experience, add content or fix bugs. Does those affect the driver in any way?
Most mods should work just fine with vorpX. There might be exceptions to this, if a mod changes the way a games renderer works internally, that’s hard to predict. But if at all, that would only by a very small percentage of mods.