You can try to make copies of existing profiles in the config app and assign other programs to these copies. You should know what graphics engine (or at least API) the game is based on, then you can try a similar profile.
Random example: If you know your game uses the OpenGL API and and is based on the idTech engine, you could try the Quake 3 profile.
There is no guarantee that this will work, but it’s worth a try.