For control inputs like joystick movement I believe vorpx just emulates an xbox controller (or keyboard and mouse, depending on the mode you set), and this works with most games since almost everything has xbox controller support. Similar to x360ce being used to turn inputs from any generic USB controller into xbox 360 inputs. In fact, x360ce might be exactly what you need; It would allow you to bind the button and axis inputs from your custom hardware to xbox 360 equivalents.
Be aware that multiplayer games with anti-cheat software may see controller emulation as a cheat.