I’ve created and added a profile that enables Geo3D for Layers of Fear. Start the game in the directory with Layers of Fearsub.exe, you might have to change the gamma in game as it was too dark for me in the Rift compared to a monitor.
I can run the game with all settings on high and use DSR on 1.5 without frame rate loss on a GTX 970.
There are some graphical glitches which seem to be based on positional headtracking so you might want to disable it if you can stomach it and it bothers you.