I have this issue when using multiple monitors and I want to tweak settings in the vorpx menu, my cursor will sometime leave the game window after selecting a setting. Its just kind of annoying to have to take the headset off every time I want to tweak a setting in the vorpx menu. Basically my mouse cursor travels to a different monitor than the monitor the game is being displayed which moves the game into a background task.
This makes it very slow to change vorpx settings because it kicks the game and the vorpx settings into the background and I have to alt tab back into the game every time I click something in the vorpx menu.