Hi Veritas,
If you didn’t go through the complete trouble shooting sticky above already, please take a look at it. Other than that you could try to reinstall vorpX, ideally after restarting Windows. If absolutely nothing works something has to be seriously wrong. Maybe your installation is corrupt for whatever reason.
Two hints for Skyrim: Check whether there is a d3d9.dll present in your game directory (for example from one of those highly popular ENB mods) and remove/rename it. Regarding the shortcut, plase make sure to use TESV.EXE as the shurtcut target, not the launcher!
Also please write a mail to support |at| vorpx com with some additional info (basic system specs and games you tried) so that we can trouble shoot this further. Thanks.