Heavily invasive anticheat software like BattleEye etc. usually prevents vorpX from hooking at all. Games with more lightweight approaches may technically work, but whether or not that potentially violates a game’s license agreement, only the game dev can tell you.
That said, e.g. various Battlefield games, Elder Scrolls Online, Fallout 76, World of Warcraft and other games have been played by users for years. I can’t guarantee anything though.