TRINE 4 causes some serious stuttering among other troubles on my system, once i am playing it on any virtual desktop, regardless if it´s vorpX, Bigscreen-Beta or Steam´s VD.
While it is stuttering in VR, there ain´t any problem on the monitor. Someone told me he doesn´t have any problem in VR, but i still think it is rather the game causing the troubles on many machines in VR than it is really system related, especially now that i read this here.