Thanks for the answer Ralf!
No, i don’t do anything special, it’s running in true fullscreen mode. This happens even with only DK2 as a display, not only in extended mode, which makes no sense at all. Same thing when i select my regular TV as the only screen, the game runs in VorpX mode but the “multi cursor” error doesn’t disspapear.
D2R does not work for me in Skyrim, i get the following error when launching the game in that mode:
Other games like Alan Wake or Mirror’s Edge work just fine. By the way, i’m using Windows 8.1, R9 280X
I hope this feedback helps!