Hi Alex
Just to be sure: Please double check that ‘vorpX Control’ is running. It shows a tray icon in your taskbar when it runs.
If you verified that vorpX Control is running and you still have issues with everything you try, it is very likely that something on your PC interferes with vorpX. There a are lot of programs that hook into games similar to vorpX and may cause problems.
First and foremost double and triple check for really everything that can show content over games. Chat programs like Skype, X-Fire, Evolve etc. and video recording software of all kind are hot candidates, and also anti-virus programs of course.