Probably an injection conflict with some other program on your PC that also hooks into games or prevents vorpX from doing so.
Typical candidates are overzealous virus scanners, any sort of CPU/GPU utility, chat applications, video recording/streaming software and generally everything that can display notifications in games.
Best way to troubleshoot this is to disable/uninstall programs that are running in the background.
If that does not help, please check the trouble shooting guide in the vorpX help for some additional information.