“failed to initialize render” in Skyrim can mean that the game runs at a resolution that is not supported by the headset. Make sure to set the resolution to 1920×1080 (DK2) or 1280×800 (DK1). Also try to change the “graphics adapter” in the launcher options.
This will become less problematic with the next vorpX version, which will allow you to use almost every resoution you want.