First time I hear of something like that. Only thing I can imagine is that something doesn’t work right in regard to vorpX’s special handling of the additional virtual monitor that the Oculus software creates for its desktop feature. This special handling is only required on a minority of systems, so you could try to disable it.
1. Click the Windows start button
2. Enter ‘services.msc’ (without the quotes)
3. Double click the ‘vorpX Service’
4. Stop the service and set its start type to ‘Deactivated’
Unless you happen to be affected by the issue this service addresses, disabling it has no negative side effects.
BTW: vorpX doesn’t do anything while it is not running (indicated by the icon in the taskar tray), not even the service. So if you also encounter this issue after exiting vorpX from the tray menu, it’s 100% unrelated to vorpX.