SteamVR has to running or vorpX will not work.
Other than that: there might be an injection conflict with some other program on your PC. Many programs also hook into games and can cause such an issue. Not all of them are obvious.
Hottest candidates are: virus scanners, any sort of CPU/GPU utilities, game video recording/streaming software, chat programs and generally everything that can show notifictations in games.
Best way to trouble shoot is to disable/uninstall every background program that would not be there after a fresh, Microsoft only Windows install.
If you can’t solve the issue this way, please try to start a few games, then create a trouble shoot data archive in the vorpX config app and send me this archive. I will then check whether I can find something that you may have overlooked.