The list of supported programs is growing constantly, you can check it here: https://www.vorpx.com/supported-games/.
If your game is based on DX9-DX11 there is a pretty good chance that it will still work with vorpX despite not being on the list. There are no guarantees for unsupported games, but vorpX provides the most important VR functionality like head tracking, image-prewarp etc. for many more games than we tested so far, just stereo 3d will probably be missing in such cases.