I think it depends on the game.
As far as I know, all graphics options are working with Z3D.
Some games don’t like DLSS (which I don’t think is very useful in VR if you use it to lower resolution, because it makes games looks blurry in my experience).
You have an option G3D shadow in VorpX ingame menu to enable/disable effects which may works or not according to the game environnements (usually, interiors allow more effects than exteriors). Auto seems to be the best, and turn off disable everything that doesn’t works well.