Windows Security first put the main vorpx.exe and another .exe in quarantine, I then added the vorpx folder to exclusions, now its stoping from hooking by canning the *.tmp files that I presume are generated by vorpx in c:/windows/temp/
PUBG uses a anticheat software that prevents other programs to hook into the game.
You can circumvent that by playing in borderless fullscreen mode with the vorpX desktop viewer instead. Obviously a relatively poor substitute for what vorpX can do if hooked into a game, but better than nothing.
And that are only the officially supported games. There are literally hundreds of user profiles for many, many other games. Not much can be done though in cases where games actively prevent other programs from hooking into them.