I know that you like to tweak, and I know that it’s tempting to ‘optimize’ for your own needs, but all I can say, especially after the latest update, is: don’t disable the settings optimization.
What you learned the hard way in regard to Witcher 3 is true for many, many more games: vorpX tweaks settings the way that are best for it. Disabling this feature will cause you more problems like this one that simply aren’t there if you just let vorpX do its job.