There are two ways to deal with potential hooking issues:
1. Try the new alternative hooking method (can be enabled in the config app). Caveat: this method is NOT FOR GENERAL USE, only try it in case of issues with regular hooking. Always try both methods if you encounter issues with hooking a game.
2. Create a desktop shortcut to the game’s main .exe from vorpX’s tray icon right click menu. Doesn’t work with most Steam/Uplay/Origin games, but should work with most GOG games.
If none of that helps, please make sure that no program is running in the background that also hooks into games or might interfere otherwise. E.g. virus scanners, any GPU/CPU utility, video streaming/recording apps, messengers. Generally everything that can show notifications in games.