Some games do not allow mouse and gamepad input at the same time. Since vorpX often emulates a mouse for head tracking it has a built in gamepad to mouse/kb mapper to deal with such conflicts. This way you can still use your gamepad together with vorpX’s head tracking mouse emulation although normally that wouldn’t work in a game.
So, whenever this feature is enabled for a profile, there is usually good reason for that. Disabling it would probably cause the above mentioned input conflict between head tracking and gamepad input. If you still want to try, you can disable it on the Input page of the vorpX ingame menu (X-Box Gamepad Override).