Yeah…. I can only get Skyrim to work, and that’s about it. Tried to get GTA V, Metro: Last Light and other games. Just doesn’t hook in at all… :S.
I did alot of the same stuff you did as well. I’m on the latest version of VORPX I believe, 0.9.1 beta.
Latest Nvidia Driver, with 3D off, tried with MalwareBytes off, tried launching GTA in diff compatibility modes. Running Windows 10 64bit, GTX 980 TI. Tried to run with Admin rights, but that seems to cause more issues.