It works for me.
Is it Standard Edition (V1.0.0.7) or Enhanced Edition ? Steam version or else ?
You should use VorpX V24. Virtual Monitor is very useful with Metro games (unless you have the same ratio and resolution on your VR headset and your physical monitor, but I doubt it).
There are a few subtleties because there are a lot of versions of this game, and a lot of ways to play this game with VorpX, but it should work. At worse, when a game doesn’t hook, remember you can always use VorpX Desktop Viewer without hooking (“Pause Watcher” or Exclude Game), but you won’t have 3D, etc.
But with Metro Exodus I recently tried VorpX with a lot of versions, and it was always working.
All informations are here :
Is Metro Exodus Enhanced working for anybody?