You’ve just got to start Vorpx and then start the game. Vorpx will hook the game without a profile. If the game is running dx12, vorpx will prompt you to install a hook helper.
You’ll only get 2d without a profile, so you need to set it appropriately in vorpx config. If the game doesn’t get hooked while vorpx is running, there’s something wrong with you environment in general. You can use the troubleshooting tool to pull up a log file and check for any errors that may be occurring.