It has to be something to do with the Origin client, right? Unlike the previous games I think it has to always be active in ME3 due to the multiplayer part, or something like this? Then Origin is interferring with Vorpx? I’ve tried a bunch of things like removing the igo64.dll file in Origin to disable the overlay but still no success. Maybe it would work to have a cracked version that can somehow start ME3 without Origin?